An accumulation of twisted protein (A protein in the body that aids in stabilizing the proteins that support the structure and shape of neurons and cellular transportation. Tau are abundant in neurons in the central nervous system and are less common elsewhere. Misfolded tau can no longer stabilize microtubules, and this pathology may harm brain cells. Researchers are currently investigating how the later accumulation of... More protein) fragments inside nerve cells. Neurofibrillary tangles are one of the characteristic structural abnormalities found in the brains of people with Alzheimer’s disease. Upon autopsy, the presence of myloid plaques and neurofibrillary tangles is used to positively diagnose Alzheimer’s disease.
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