Apolipoprotein E is a cholesterol transport protein and has been found in the amyloid plaques in Alzheimer's disease. It comes in several types or “alleles” – 2, 3, and 4. Each person has two alleles (one from each parent) which you can have in any combination of the three types. Apolipoprotein E-4 has been shown to increase the risk of Alzheimer’sA progressive, degenerative form of dementia that causes severe intellectual deterioration. The first symptoms are impaired memory, followed by impaired thought and speech, an inability to care for oneself and, eventually, death. Onset can be associated with or preceded by depression.... More disease but does not cause Alzheimer’sA progressive, degenerative form of dementia that causes severe intellectual deterioration. The first symptoms are impaired memory, followed by impaired thought and speech, an inability to care for oneself and, eventually, death. Onset can be associated with or preceded by depression.... More disease, whereas apolipoprotein E-2 decreases the risk of Alzheimer’sA progressive, degenerative form of dementia that causes severe intellectual deterioration. The first symptoms are impaired memory, followed by impaired thought and speech, an inability to care for oneself and, eventually, death. Onset can be associated with or preceded by depression.... More disease. Apolipoprotein E-3, the allele that occurs most commonly, neither increases nor decreases the risk of Alzheimer’sA progressive, degenerative form of dementia that causes severe intellectual deterioration. The first symptoms are impaired memory, followed by impaired thought and speech, an inability to care for oneself and, eventually, death. Onset can be associated with or preceded by depression.... More disease. (Finding out one’s apolipoprotein E type is NOT a genetic test for Alzheimer’sA progressive, degenerative form of dementia that causes severe intellectual deterioration. The first symptoms are impaired memory, followed by impaired thought and speech, an inability to care for oneself and, eventually, death. Onset can be associated with or preceded by depression.... More disease. Although more people with E-4 eventually get the disease than those with E-3 or 2, some people with E-4 never get Alzheimer’sA progressive, degenerative form of dementia that causes severe intellectual deterioration. The first symptoms are impaired memory, followed by impaired thought and speech, an inability to care for oneself and, eventually, death. Onset can be associated with or preceded by depression.... More.)
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